Non invasive detection of hypoperfusion and deoxygenation by near-infrared spectroscopy (NIRS) in acute ischemic stroke

Background: Non-invasive monitoring cerebral hemodynamics and oxygenation might be of major importance in acute ischemic stroke. The aim of our study was to measure cerebral blood flow and tissue oxygenation in middle cerebral artery infarction by NIRS and indocyanine green (ICG) and compare it with perfusion-weighted MRI (PW-MRI). Patients and Methods: In 21 patients with acute infarction of the middle cerebral artery we measured cerebral perfusion by monitoring kinetics of an intravenous bolus of ICG, and tissue oxygenation 2.0±2.3 days after stroke onset. NIRS optodes were placed bitemporally with an interopt…