Correlation of Vasa Vasorum Neovascularization, Inflammation and Plaque Progression in Aortas of ApoE-/-/LDL-/- Double Knockout Mice by Micro-CT
AC Langheinrich, A Michniewicz, DG Sedding, G Walker, PE Beighley, WS Rau, RM Bohle, EL Ritman · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2006 · Heft 05
Bibliografische Angaben
Zusammenfassung
Ziele: Because of the very thin arterial wall, vasa vasorum (VV) are generally not present in mice aortas. However, as atherosclerosis in large animals is associated with increase in vasa vasorum density, we investigated whether vasa vasorum neovascularization occurs in the aorta of apoE-/-/LDL-/- deficient mice using 3-D Micro-CT and histology. Methode: Aortas from apoE-/-/LDL-/- mice at the age of 16, 18, 20 or 80 weeks were infused in situ with Microfil, harvested and scanned with micro-CT (5 and 20µm cubic voxel). Using the 3D micro-CT images, we characterized plaque volume, CT “density“ and VV luminal volum…
