5-amino salicylic acid induced depletion of glutathione protects the colon against trinitrobenzene sulphonic acid injury through heme oxygenase-1 enzyme expression

Introduction: 5-amino salicylic acid (5-ASA) is successfully used in the treatment of inflammatory bowel disease (IBD). The better understanding of the mechanism of action of 5-ASA may lead further insight to the etiology of IBD. We know that oxidative stress plays a key role in causing inflammation. Thus, antioxidant enzyme systems have an important defensive function. The induction of the antioxidant systems, heme oxygenase-1 (HO-1) enzyme and glutathione (GSH) are involved in the maintenance of intestinal mucosal integrity. Aim: We examined the effect of the 5-ASA-provoked GSH depletion for the role of HO-1 i…