The potential tumormarker PIBF is elevated in colorectal and pancreatic cancers
T Micsik, B Polgár, E Schäfer, K Diófalvi, K Rásky, F Péterfy, F Hollósy, Á Pap, J Szekeres-Bartho, R Schwab, L Kopper, I Peták · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Introduction: PIBF (Progesterone Induced Blocking Factor) is a peptide secreted by lymphocytes upon progesterone stimulation and causes a Th1>Th2 shift which is a strong protective factor for the embryo during pregnancy. This Th2 shift and the lower activity of NK-cells might also create favorable condition for tumor progression. Investigations showed that PIBF is elevated in rapidly proliferating cancer cell lines and malignant tumors. Aim of the study: was to strengthen the tumor marker role of PIBF in gastrointestinal malignancies. Methods: Urine samples were obtained from 25 patients with colorectal, pancrea…
