Post-prandial insulin sensitization. new perspectives for gastrointestinal endocrinology

Eating a meal has been found to activate a parasympathetic reflex in the liver that through the release of a hepatic insulin sensitizing substance (HISS) into the circulation sensitizes peripheral tissues to the hypoglycaemic effect of insulin. Partial hepatic sensory denervation (PHSD) was achieved by a 3-day perineurial treatment with 2% capsaicin solution around the anterior hepatic plexus in male guinea-pigs, rats or rabbits to confirm the sensory nature of the HISS mechanism in these species. One week later, hyperinsulinaemic (100µU/ml) euglycaemic (5.5 mmol/l) glucose clamp were performed to estimate whole…