Regulation of parameters of the metabolic syndrome in ERbeta -/- mice

Aims: Gender differences in cardiovascular disease are gaining importance in diagnosis and therapy. However, the molecular mechanisms of these differences are widely unknown. Estrogen receptors (ERs) belong to the family of nuclear hormone receptors and have been suggested to play an important role in the molecular mechanisms underlying the gender differences in metabolic disorders. We could recently demonstrate that ERbeta suppresses the activity of Peroxisome proliferator-activated receptor gamma (PPARgamma) in vitro. PPARgamma is known as an important regulator of insulin and glucose metabolism. The aim of th…