Buffering Acidosis during Permissive Hypercapnia to Restore Physiologic PH May Increase the Degree of Lung Injury in Surfactant Deficient Rabbits
HD Hummler, A Engelmann, A Merinsky, S Häring, AR Franz, M Ebsen, MR Wolfson, F Pohlandt · Zeitschrift für Geburtshilfe und Neonatologie · 2006 · Heft 11
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Zusammenfassung
Background: Buffering hypercapnic acidosis is commonly performed in the ICU when patients with respiratory failure are exposed to permissive hypercapnia. Objective: To study the hypothesis that buffering hypercapnic acidosis worsens the degree of lung injury in an animal model of surfactant deficiency. Methods: 28 anesthetized, surfactant-depleted rabbits were mechanically ventilated with an FiO2=1.0, Vt=4.5ml/kg, PEEP=6cmH2O with the rate adjusted to obtain a target PaCO2=75–85mmHg, and were randomized into a buffer group (receiving NaHCO3 infusions to restore pH >7.25) and a control group. Surviving animals we…
