Intra-individual propofol dosage variability in children undergoing repetitive procedural sedations

Objectives: Propofol sedation/anesthesia has been used successfully in children undergoing procedural sedation. We prospectively assessed intra- and inter-individual variability in propofol dosage for sedation in repetitive procedures in children with malignancies. Patients and methods: A total of 80 procedures including lumbar puncture, radiation therapy, magnetic resonance imaging, bone marrow biopsiy, endoscopy, drainage of ascites (range: 2–19 procedures/patient) were performed in 24 children (mean age: 9,6±5,4 years). The mean propofol induction dose was 2,61±0,74mg.kg-1 to achieve deep sedation. Primary ou…