Intestinal permeability, bowel wall thickness and bacterial biofilm in patients with chronic heart failure compared to healthy controls
A Sandek, A Swidsinski, J Bauditz, S Buhner, J Weber-Eibel, S von Haehling, W Doehner, M Rauchhaus, H Lochs, S Anker · Aktuelle Ernährungsmedizin · 2006 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Chronic heart failure (CHF) is a state of chronic inflammation. Bacterial endotoxin and translocation may contribute to this inflammatory status. Gut morphology and barrier function have never been studied in detail in CHF patients. Methods: We studied 22 CHF patients (age 67±2 years, LVEF 31±1%, NYHA class 2.3±0.1, peak VO2 15.0±1.0 mL/kg/min) and 22 control subjects (62±1 years, LVEF 68±2%, peak VO2 24.7±1.3 mL/kg/min). Bowel wall thickness was investigated by transcutaneous sonography, small intestinal permeability by lactulose-mannitol test, passive carrier-mediated transport by D-xylose test, la…
