In vivo selection of liver cells in a model of allogeneic bone-marrow-transplantation
K Streetz, R Doyonnas, D Jenkins, S Perryman, S Lin, C Trautwein, J Shizuru, H Blau, K Sylvester, M Kay · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Expansion of transplanted cells is a common goal for cellular therapies. As the available amount of liver cells for transplantation is limited we aimed to explore new resources for replacement therapies, such as intra- and extrahepatic stem cells. Methods: We performed allogeneic Bone-marrow-transplantation (BMT) in balb/c mice. Hepatocyte transplantation was carried out subsequently. Transgenic FVB-mice expressing human alpha-1-antitrypsin (hAAT) under the liver specific hAAT-promoter were used as BM and hepatocyte donors. Results: After subsequent allogeneic BM and hAAT(+) hepatocyte transplantation we o…
