Metabolic characteristics of blood monocyte derived Neo-Hepatocytes from patients with alcoholic liver disease and corresponding controls

Aims: End stage liver disease is a leading cause of death worldwide. At present the sole definitive treatment for severe liver failure is liver transplantation thus, shortage of donor organs raises demand for new therapeutic options. In this regard hepatocyte-like (NeoHep) cells have been established by trans-differentiation of peripheral blood monocytes, with the intention to bridge liver function. Methods: NeoHep cells from blood monocytes of alcoholic patients and healthy controls were generated by trans-differentiation. Their comparison to primary human and mouse hepatocytes display a similar morphology and…