Consensus definitions of renal function in hepatorenal syndrome (HRS) are inconsistent – excellent potential of MDRD calculated glomerular filtration rate

Background and Aims: Discrimination of HRS type 1, associated with an ominous progno-sis from HRS type 2 and, moreover from normal renal function is of great clinical importance in patients with cirrhosis. The consensus definition (Hepatology 1996;23:164–176) of HRS type 1 comprises a serum creatinine concentration (Crea) above 2.5mg/100ml or a creatinine clearance (CrCl) below 20ml/min with cut-off values for normal renal function of 1.5mg/100ml or 40ml/min. Unfortunately, most studies on renal function in cirrhosis excluded pts. with HRS and the accordance of the cut-off values above has not been investigated.…