Progression-specific Genes Identified by Expression Profiling of Matched Ductal Carcinomas in situ and Invasive Breast Tumors, Combining Laser Capture Microdissection and Oligonuc…

In breast cancer the progression of DCIS (ductal carcinoma in situ) to IDC (invasive ductal carcinoma) is a crucial step in developing metastasis–the major cause of mortality from malignant tumours. Understanding the molecular events accompanying this transition will be the basis (1) to improve the classification in high- and low-risk groups for DCIS patients according to risk of relapse or progression and (2) to advance in individualizing therapy for DCIS and IDC patients. In order to identify new prognostic markers and drug targets correlated with breast cancer progression, we combined Affymetrix microarray an…