[18F]fluordeoxyglucose positron emission tomography in spinocerebellar ataxias type 1,2,3 and 6

Introduction: The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal dominant ataxias. Some mutations, including SCA 1,2, and 3 are multisystemic disorders, characterized by a variety of noncerebellar symptoms, while others, like SCA 6, give rise to a pure cerebellar syndrome. Functional imaging studies so far have reported decreased glucose metabolism in the cerebellum and brainstem. The present study therefore aimed to identify specific local cerebral metabolic patterns associated with a given SCA mutation using [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Meth…