Intake of anti-epileptic drugs is associated with folate deficiency
A. Scholz, S. Moskau, K. Wefer, B. Stoffel-Wagner, A. Semmler, C. Hoppe, B. Jung, G. Widman, C. Helmstaedter, C.E. Elger, M. Linnebank · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Several small studies have suggested that patients with epilepsy who take anti-epileptic drugs (AED) have an increased prevalence of folate or vitamin B12 deficiency. Methods: We analyzed plasma folate and vitamin B12 levels in 697 inpatients during 2005. The normal range of folate (3–17ng/ml) and vitamin B12 (180–920pg/ml) was veryfied in 200 healthy blood donors. Prevalences of vitamin deficiency in patients and controls were compared with age and gender as covariables in nominal logistic regression analysis. The predictive character of age, gender and vitamin b12 deficiency for folate deficiency in the…
