Bilateral language representation in congenital callosal agenesis

Here, we report the results of fMRI during language comprehension in Congenital Callosal Agenesis (CCA), a very rare disconnection syndrome. In most humans, language is lateralized to the left side of the brain. Left-sided brain lesions acquired early in life may result in bilateral language representation. Therefore, bilateral development of usually distinct lateralized functions could be assumed as a compensatory mechanism. The presence of an intact and often hypertrophied anterior commissure in acallosal brains implicates that the increasing use of noncallosal commissures might be a further possible substitut…