BDNF causes complex modifications of cortical neurotransmitter protein expression in the rat cortex after photothrombotic ischaemia

Functional reorganization of the cerebral cortex following cerebral ischemia is associated with structural remodeling reflected by changes in expression patterns of a battery of different proteins. Trophic substances, such as brain-derived neurotrophic factor (BDNF) and granulocyte-colony stimulating factor (G-CSF), have been shown to influence these processes and improve postischemic outcome. Since neurotranmitter receptors are major candidate molecules to be modified in the postischemic reorganization phase, we checked for alterations of postischemic protein expression patterns and potential modifications by B…