Quantified metabolite alterations in 1H-MR spectroscopy correlates with hippocampal cell loss and astrogliosis in patients with intractable temporal lobe epilepsy
T. Hammen, M. Hildebrandt, M. Dölken, T. Engelhorn, E. Pauli, F. Kerling, A. Stadlbauer, J. Romstöck, O. Ganslandt, C. Nimsky, A. Dörfler, H. Stefan, I. Blümcke · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Proton-MR spectroscopy (1H-MRS) was applied as a non-invasive technique to asses the severity of hippocampal pathology in patients with chronic temporal lobe epilepsy (TLE). 1H-MRS was carried out in the hippocampus of 23 unilateral TLE patients prior to their submission for hippocampectomy. Surgical specimens of the same patient cohort were neuropathologically examined and neuronal cell numbers/astrogliosis microscopically determined. Quantified metabolite alterations in 1H-MRS (N-acetylaspartate and N-acetylaspartyl-glutamate – tNAA; myo-Inositol – m-Ins; choline – Cho; creatine – Cr; total glutamate and gluta…
