Ginkgo-biloba-Extract EGb 761®, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: A randomised, double-blind trial

In an exploratory trial we enrolled 94 outpatients, aged 50 years or above (mean age 67.4 years), suffering from mild to moderate Alzheimer's disease with neuropsychiatric features. To be eligible, patients had to fulfil the NINCDS/ADRDA diagnostic criteria for probable Alzheimer's disease, score below 36 on the TE4D, a brief screening test for dementia, below 6 on the Clock-Drawing Test (Sunderland scoring) and between 9 and 23 on the Syndrome Kurz-Test, a cross-culturally validated cognitive test battery. Their total score on the 12-item Neuropsychiatric Inventory had to be at least 5, with at least one item o…