Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease – results of a prospective study
J Seiderer, S Brand, KA Herrmann, F Schnitzler, R Hatz, A Crispin, S Pfennig, SO Schoenberg, B Göke, P Lohse, T Ochsenkühn · Zeitschrift für Gastroenterologie · 2006 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background/Aim: The diagnostic and therapeutic relevance of CARD15 genotyping in Crohn's disease (CD) has not been investigated so far. We therefore performed a prospective study analyzing whether CARD15 variants are independent predictive factors for small bowel stenosis in CD with potential implications for patient management. Methods: Eighty CD patients with clinical symptoms suggestive of a small bowel stenosis were included. All patients were genotyped for the CARD15 variants c.2104C>T (p.R702W), c.2722G>C (p.G908R), and c.3019_3020insC (p.Leu1007fsX1008), and were examined by magnetic resonance enteroclysi…
