Does ghrelin increase during nausea?

The appetite stimulating hormone ghrelin is mainly secreted from the stomach was found to reduce emesis in a chemotherapy induced nausea model in ferrets when given intra-peritoneally. The mechanism of its anti-emetic activity is not yet clear. Therefore, we investigated ghrelin levels during motion sickness induced nausea. Methods: Eight healthy male subjects (24.8±1.4 years) being susceptible to vection were recruited to our test procedure. To induce nausea a slow rotation procedure (120° per s) around the vertical axis for 1min with head movements was used. After a break (1min) rotation was repeated until nau…