Effects of Hyperglycemia on Angiogenesis in Human Placental Endothelial Cells
Turkan Yanik, Ertan Katirci, Mehmet Simsek, Emin Turkay Korgun, Dijle Kipmen-Korgun · Zeitschrift für Geburtshilfe und Neonatologie · 2024 · Heft 04 · S. 346-354
Bibliografische Angaben
Zusammenfassung
AbstractThe placenta is a temporary organ that provides communication between the mother and fetus. Maternal diabetes and abnormal placental angiogenesis may be linked. We investigated the angiogenesis mechanism resulting from VEGF and glucose stimulation in PECs obtained from human term placenta. Immunohistochemistry was performed to characterize PECs obtained from human term placenta. D-glucose was added to the medium containing PECs to establish normoglycemic and hyperglycemic conditions. The expression levels of VEGF, VEGFR-1 and VEGFR-2 genes and proteins in PECs from the control and experimental groups wer…
