MR-morphometry – an overview

The investigation of structural brain changes with magnetic resonance imaging (MRI) is increasingly used for research on healthy individuals and examination of patients to identify structural correlates of covariates of interest (i.e. disease progression, neuropsychological scores). While in the beginning mostly manual delineation of regions of interest were performed, automated computer-based processing is more and more applied, allowing larger sample sizes to be included in studies without the need to define regions of interest a priori. The most widely used technique is voxel based morphometry (VBM), adopted…