Effectiveness and tolerability of topiramate in the treatment of epilepsy in elderly patients with new onset vs. longer duration epilepsy

Objective: To explore seizure and tolerability outcomes of topiramate (TPM) in mono- or combination therapy in elderly patients with epilepsy with either new onset (NOE) or longer duration epilepsy (LDE). Methods: Prospective, single arm, multicentre phase IV clinical trial (TOP-GER-13). Patients ≥60 years of age were followed for 12 months. Doses of TPM and concomitant antiepileptic drugs could be adjusted individually. Seizure frequency and adverse events were documented at each visit. Results: 107 patients (53% male, mean age 69±7 years) were enrolled. NOE (disease duration