CXCR3 promotes cerebellar inflammation but prevents ocular destruction in transgenic mice with a TH1-driven neuroinflammation

CXCR3 and its ligands are important for the trafficking of activated TH1 T-cells during inflammation. Recent functional studies demonstrate a more diverse role of CXCR3 in inflammatory CNS diseases. In EAE, the animal model for MS, CXCR3 does not promote the influx of encephalitogenic T cells into the brain but restricts the invasion of effector T cells into the parenchyma, thereby exerting a protective effect. However, EAE has a very complex pathogenesis in which a multitude of different inflammatory cell types are involved. We examined the impact of CXCR3 on a less complex IFN-gamma-dependent TH1-driven CNS im…