Laminin–1 decreases estrogen receptor β expression in breast cancer cells

Estrogen receptor (ER) β is involved in developmental processes of the mammary gland and also seems to play an important role in breast cancer. Up to now six splice variants of ERβ have been identified but their specific functions remain to be examined. The aim of this project was to determine whether the expression of ER β isoforms is influenced by extracellular matrix and basement membrane components. In matrigel-assays MDA-MB 231 breast cancer cells were plated on “Matrigel™ Basement Membrane Matrix“. As control the same amount of cells was cultured on uncoated tissue culture plastic. To find out which specif…