CareLit Fachartikel
A novel experimental model for investigating the molecular causes of congenital birth defects in diabetic pregnancy
SG Woodruff, M Loeken, K Kapelle, C Bartz, B Lüscher, W Rath · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
913654
CareLit-ID
Jahr
2008
Publikation
PDF
nein
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DOI
ja
zitierfähig
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Zusammenfassung
Introduction The offspring of women with diabetes mellitus are at increased risk for both neural tube defects (NTD) and congenital heart defects (CHD). Interestingly, hyperglycaemia-induced oxidative stress represses embryonal transcription of Pax3, a primary lineage-control gene required for neural tube closure and formation of neural crest-derived cardiac outflow tracts. Impaired expression of Pax3 during embryonic stem cell differentiation may be the main cause of NTD and CHD during diabetic pregnancy. The specific mechanism by which sublethal oxidative stress represses Pax3 gene transcription remains, howeve…
Schlagworte
P19 embryonal stem cells
Pax3 expression
congenital birth defects
diabetic pregnancy
oxidative stress
Geburtshilfe und Frauenheilkunde
