Breast cancer metastasis – a target for cyclooxygenase inhibitors?

In recent studies it was shown that COX2 is overexpressed in about 40–50% of human breast cancer samples. There are also studies that suggest an enhancing effect in the development of metastases in breast cancer by COX2. Although COX2 does not seem to be the only promoter of this process, it is a drugable target and therefore of great interest. In this study we analyzed 189 paraffin embedded breast cancer tissue samples and 61 matching lymphnode metastases for COX2 expression. Additionally we analyzed 36 bone and 17 brain metastasis and their matching primary tumor samples. Clinical data available from neoadjuva…