Cellular Immune Activation and Clinical Manifestation of Functional Dyspepsia

Aims: Immune activation is believed to play a critical role for the manifestation of functional gastrointestinal disorders (FGID). In recent studies we have demonstrated an association of cellular immune activation and symptoms in patients with FGID (Gastroenterology, 2007, Mar; 132(3):913–20). We hypothesized that the release of cytokines from peripheral blood mononuclear cells (PBMC) is linked to the severity of symptoms in patients with functional dyspepsia (FD). Thus we aimed (1) to compare the release of cytokines from PBMC in patients with FD and healthy controls (HC) and (2) to correlate symptom severity…