Prognostic role of M65, the biomarker of overall cell death, for the clinical course of acute liver failure

Aims: Acute liver failure (ALF) is the final common pathway of severe hepatocyte destruction and one of the most dangerous complications in hepatology. This disease entity is associated with a high rate of mortality and only sparse prognostic markers for clinical outcome are currently available. Therefore, the AIM of this study was to define and elucidate peripheral markers of total cell death and apoptosis in particular, as cell death is believed to play a crucial role in the pathogenesis of ALF. Methods: Our prospective study (01/2006–02/2008) included 26 patients [15 females (58%) at 38±2.7 years of age] with…