Mechanisms by which vildagliptin reduces postprandial glucose excursions in patients with type 2 diabetes
J Wörle, T Lindenberger, M Albrecht, R Linke, JE Foley, MA Ligueros-Saylan, R Sabo, Y Zhan, YL He, C Beglinger, B Göke, J Schirra · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objective: The dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptine (VILDA) increases postprandial (pp) GLP-1 levels 2–4 fold. Major effects of GLP-1 involve increases in pp insulin secretion, suppression of pp glucagon secretion and delay of gastric emptying (GE). The potential effects of acute 100mg Vilda p.o. adminstration on pp glucose (GLU) fluxes are unknown. Research design and methods: In this single-blind, placebo controlled, randomized study gastric emptying (scrambled eggs, jello containing 50g of glucose, 472kcal, labelled with 99mTc-Sn-colloid), total rates of glucose appearance (TRA), meal gluco…
