CareLit Fachartikel
Communication between epithelial and stromal cells
J Dittmer · Geburtshilfe und Frauenheilkunde · 2009 · Heft 02
Dokument
913977
CareLit-ID
Jahr
2009
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Epithelial-stromal interactions are critical for the development of organs, such as the mammary gland. The mammary mesenchyme is required for the initiation of mammary ductal branching morphogenesis in females and the destruction of the mammary epithelial bud in males. For both functions the mammary mesenchymal cells must be activated by PTHrP (parathyroid hormone-related protein). By binding to the PTH1 (parathyroid hormone 1) receptor PTHrP triggers the expression of the androgen receptor and activates LEF1 and β-catenin, components of the Wnt signaling pathway (Dunbar et al., 1999; Dunbar et al., 1998; Foley…
Schlagworte
Breast
Tumor
Attention
Chemokine
Lead
Geburtshilfe und Frauenheilkunde
