Hepatocyte specific NEMO deletion promotes NK/NKT cell dependent liver damage
N Beraza, Y Malato, LE Sander, M Al-Masaoudi, J Freimuth, D Riethmacher, T Roskams, C Liedtke, C Trautwein · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
The nuclear factor kappa B (NF-κB) is essential in the regulation of apoptosis, inflammation, chronic liver disease and progression of cancer. NF-κB is activated after phosphorylation of IκB by the IKK complex. The IKK complex consists in two catalytic subunits IKKa/1 and IKKb/2 and a regulatory subunit IKKγ/NEMO. We generated hepatocyte specific NEMO deleted mice (NEMOΔhepa) that exhibit chronic inflammation, steatohepatitis and HCC development. NEMOΔhepa mice are highly susceptible to TNF mediated liver damage, although the impact of other TNF-family of cytokines and their implication in the development of the…
