The role of microRNA-29 in collagen deposition during liver fibrogenesis
M Kwiecinski, I Strack, A Noetel, M Scheffler, U Töx, S Schulte, U Drebber, N Elfimova, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: MicroRNAs (miRNAs) are endogenously expressed regulatory noncoding RNAs, repressing protein translation by binding to their target mRNAs. In the present, study we investigated the role of the members of the miRNA-29 family in regulation of extracellular matrix production during liver fibrogenesis. Methods: In order to identify miRNA species involved in repression of collagen synthesis, the databases of Miranda, Targetscan and Pictar were screened. MiR-29a and miR-29b were analysed during in vitro induced myofibroblastic differentiation of primary hepatic stellate cells (HSC), in human biopsies of chronical…
