CareLit Fachartikel
TGF-β induces IL-15 in hepatocytes. Is it then opposing TGFβ in a negative feedback manner? Does this mechanism play a role in liver disease?
S Munker, P Godoy, E Bulanova, H Weng, A Bachmann, S Bulfone-Paus, S Dooley · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
914045
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Liver fibrogenesis is a process involving the participation of several cellular components. We described a new role for hepatocytes in the process of fibrogenesis, in which TGFbeta induces expression and secretion of CTGF, another potent profibrogenic cytokine. Recently Interleukin-15 has emerged as a new player in several models of liver damage, but its precise role has not yet been determined. Real Time PCR showed that TGFbeta induces IL-15 mRNA up to 80 fold after 24h in primary hepatocytes, and up to 10 fold in AML12 cells. Using chemical inhibitors we determined that although ALK5 activity is essential, ERK…
Schlagworte
Liver disease
Liver fibrosis
TGFbeta
il-15
Cytokine
Binding Sites
Apoptosis
After
Zeitschrift für Gastroenterologie
