Role of FGFR4 signaling in human hepatocellular carcinoma
F Bott, C Schíller, C Schlaeger, A Mehrabi, B Radlwimmer, P Schirmacher, T Longerich · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
The fibroblast growth factor receptor (FGFR) family members mediate cellular processes like proliferation, migration, differentiation and angiogenesis. They are mutated or overexpressed in several human cancers. We have previously reported upregulation of FGF19 in human HCC. Furthermore it has been shown that ectopic expression of FGF19 in skeletal muscle of transgenic mice leads to the development of hepatocellular carcinoma. Since FGF19 signaling is exclusively mediated via the FGFR4 we analyzed its role in hepatocarcinogenesis both in vivo and in vitro. Gains at the FGFR4 gene locus (5q35.2) were detected in…
