Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumor progression
U Maegdefrau, T Amann, A Winklmeier, S Braig, T Schubert, TS Weiss, K Schardt, C Warnecke, AK Bosserhoff, C Hellerbrand · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Striking similarities exist between molecular mechanisms driving embryonic liver development and HCC progression. Bone morphogenetic proteins (BMPs), particularly BMP4, have been proposed to regulate embryogenic hepatic development. However, BMP expression levels have not been analyzed in HCC. The aim of this study was to determine the expression and biological role of BMP4 inhuman HCC. Methods and Results: BMP4 mRNA and protein are up-regulated in HCC cell lines and tissue compared to primary human hepatocytes and non-tumorous tissue. Hypoxia further induced BMP4 expression in HCC cells and this induction was a…
