CareLit Fachartikel

Chemotherapy-induced apoptosis in hepatocellular carcinoma (HCC) involves activation of the p53 family and is mediated by signaling via death receptors and mitochondria

SJ Seitz, AE Schulze Schleithoff, AF Koch, K Lorenz, W Stremmel, M Müller · Zeitschrift für Gastroenterologie · 2009 · Heft 01

Dokument
914056
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
SJ Seitz, AE Schulze Schleithoff, AF Koch, K Lorenz, W Stremmel, M Müller
Ausgabe
Heft 01 / 2009
Seiten
–
Erschienen: 2009-01-20 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1191902

Zusammenfassung

In HCC patients, conventional chemo- and radiation therapy fail. This failure is mainly due to resistance towards apoptosis. Therefore, current attempts to improve the survival of HCC patients will have to include strategies that specifically target tumor cell resistance towards apoptosis. However, the molecular determinants, which confer resistance of HCC cells towards chemotherapeutic agents, have not yet been fully elucidated. We investigated the mechanisms by which chemotherapeutic drugs elicit apoptosis in hepatocellular carcinoma. DNA damaging agents induce accumulation and activation of all three p53 fami…

Schlagworte

Chemoresistenz HCC p53 p63 p73 Apoptosis Tumor Drug Resistance Bleomycin Zeitschrift für Gastroenterologie