The scavenger receptor D6 limits acute liver damage by degradation of inflammatory chemokines after injury
M Berres, M Moreno Zaldivar, P Schmitz, K Pauels, SA Lira, C Trautwein, F Tacke, HE Wasmuth · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Chemokines are inflammatory mediators which are involved in acute liver injury. The scavenger receptor D6 is a promiscuous chemokine receptor lacking classical signalling functions. It negatively regulates inflammation by targeting CC chemokines to degradation after internalization in various tissues. However, its function in acute liver injury has yet not been analyzed. Methods: Acute liver injury was induced by injection of CCl4 (0.6mg/kg body weight) in constitutive D6-/- mice and wild-type littermates (n=6). Mice were sacrificed after 0, 24, 48 and 72 hours. The degree of liver injury was assessed by l…
