CareLit Fachartikel
Alpha v Beta 6 Integrin is a Specific Immunohistological Marker in the Diagnosis of Cholangiocarcinoma
E Patsenker, L Wilkens, V Banz, D Stroka, A Keogh, F Stickel · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
914062
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background and Aims: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the most common primary hepatic malignancies. Immunohistological differentiation of both tumors is pivotal for treatment and prognosis. Recently, alpha V beta 6 integrin (avb6) was found strongly upregulated in experimental biliary fibrosis and in patients with cholestatic liver disease, but its expression in primary liver cells and diagnostic applicability to distinguish primary cancers is unknown. Methods: 77 HCC and 73 CC paraffin-embedded tissues from patients who underwent partial hepatectomy were collected and immunostained…
Schlagworte
Cholangiokarzinom
Epithelial-Mesenchymale Transition
Integrin
Tumormarker
Tumor
Cholangiocarcinoma
Association
Diagnosis
Zeitschrift für Gastroenterologie
