BAL ELISPOT and NAT for the diagnosis of smear-negative tuberculosis
C Jafari, A Bossink, M Losi, D Goletti, R Eberhardt, M Ernst, S Thijisen, A Strassburg, U Greinert, S Winteroll, B Kalsdorf · Pneumologie · 2009 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: We present an interim analysis of a study of the European Tuberculosis Network (TBNET) on the comparison of a Mycobacterium tuberculosis (MTB) specific ELISPOT performed on cells from the bronchoalveolar-lavage (BALMCs) and from peripheral blood (PBMCs) and MTB-specific nucleic acid amplification technique (NAT) for the rapid diagnosis of smear-negative pulmonary tuberculosis (pTB). Methods: Following informed consent, patients with a medical history and a pulmonary infiltrate compatible with pTB and negative AFB smear results were prospectively enrolled in the study. MTB-specific NAT on BAL and MTB-…
