Serum FGF21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia
T Ebert, S Stein, H Stepan, J Kratzsch, M Verlohren, HJ Verlohren, K Drynda, U Lössner, M Blüher, M Stumvoll, M Fasshauer · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Fibroblast growth factor 21 (FGF21) was recently introduced as a novel adipokine with beneficial effects on glucose homeostasis and insulin sensitivity. In contrast to other adipokines including adiponectin and leptin, concentrations of circulating FGF21 have not been evaluated so far in gestational diabetes mellitus (GDM). In the current study, we investigated serum concentrations of FGF21 in patients with GDM as compared to healthy pregnant controls matched for gestational age and fasting insulin. Methods: FGF21 was determined by ELISA in control (n=80) and GDM (n=40) patients and correlated to cli…
