NK cells engineered to express the chimeric receptor scFv(ch14.18)-zeta-specifically lyse GD2 expressing neuroectodermal tumors
D Seidel, N Huebener, D Pferdmenges, T Müller, W Wels, U Koehl, R Esser, M Bleeke, A Shibina, A Stermann, G Gaedicke, HN Lode · Klinische Pädiatrie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Neuroblastoma (NB) and melanoma are neuroectodermal tumors characterized by poor prognosis. The T cell independent antigen ganglioside GD2 is highly expressed on most NB and on 30% of melanomas, which makes it an interesting target for immunotherapeutic approaches. NK cells are able to actively lyse tumors with downregulated MHC class I expression due to their MHC-independent target cell recognition. In order to provide for a specific recognition of GD2 expressing tumor cells, the human NK cell line NK-92 was genetically modified to express a chimeric receptor, consisting of a GD2-specific ch14.18scFv-fragment a…
