Impact of the maternal age on first trimester screening for chromosomal aberrations of the fetus – Analysis of 15,228 datasets

Introduction: First trimester screening (FTS) became standard in noninvasive testing for chromosomal abnormalities in early pregnancy.1 2 The individual risk is calculated on the basis of a general background risk, which refers to the maternal age.3 A new method, Advanced Firsttrimester Screening (AFS) excludes the background risk in its algorithm.4 5 6 This study had the aim to analyze how the detection of aneuploidies is influenced by the in- or exclusion of the maternal age in the risk calculation. Material and Methods: The data of 15,228 first trimester screenings were recalculated with FTS and AFS. The stud…