Overdosed antioxidant therapy is contraindicated in fatty liver

Introduction: Alimentary induced fatty liver is associated with systemic low-grade inflammation, which changes various signal transduction pathways. Our earlier study demonstrated that antioxidant therapy could reduce tissue alterations and protect redox-homeostasis. Increasing numbers of scientific papers report serious side-effects of overdosed nutritional antioxidants, such as renal-failure and hepato-myo-encephalopathy. Because of these negative observations we decided to study a nutritional supplementation with a fruit and vegetable concentrate (OÉTI 45/É) in the model of fatty liver in “short term“ experim…