Signal transduction therapy of colon tumors with multiple target kinase inhibitors

Signal transduction therapy is a leading area of modern drug research aiming to inhibit the pathomechanism based validated target molecules in cellular signaling. Selective inhibition of these false proliferative signals via targeting receptor tyrosine kinases and other signaling enzymes, resulting in the induction of apoptosis by depletion of the survival factors is one of the most studied concept of modern chemotherapy. Our Nested Chemical Library™ (NCL) technology is based on a knowledge base approach where focused libraries of kinase inhibitors (KIs) around 108 core structures and hundreds of scaffolds are u…