Celiac disease and risk of subsequent type 1 diabetes

Earlier studies suggest that children with type 1 diabetes (T1D) are more likely to have a subsequent diagnosis of celiac disease. However, research is sparse on the risk of subsequent T1D in the population with celiac disease. Aim: to determine the risk of subsequent T1D in children, adolescents and their first grade relatives. Patients and methods: We have determined in celiac patients (n:61) and their asymptomatic family members (n: 128) the islet cell antibody (ICA/JDFU with indirect immune-fluorescence assay), glutamic acid decarboxylase autoantibody (GADA/U/ml, RIA) C-peptide (ng/ml, RIA) levels and the oc…