Tract-based spatial statistics in adult Tourette patients indicate white matter changes in the anterior limb of the internal capsule

Introduction: Tourette-Syndrom (TS) is a chronic neuropsychiatric disorder characterised by motor and vocal tics. The severity of the tics waxes and wanes over time. TS is often accompanied with comorbidities such as obsessive-compulsive disorder (OCD), depression, and ADHS. For treatment, different pharmacological strategies are available. In treatment resistant patients, deep brain stimulation offers a chance of improvement. Different target points are used currently, the medial portion of the thalamus, the internal part of the globus pallidus internus and the nucleus accumbens/anterior limb of the internal ca…