CSF Tau, phospho-Tau181 and amyloid-β 38/40/42 in frontotemporal dementia and pimary progressive aphasia

Over the past ten years, characteristic cerebrospinal fluid (CSF) biomarker patterns have been established for supporting the clinical diagnosis of Alzheimer's dementia (AD). In contrast, the literature about specific biomarkers for other frequent neurodegenerative dementias is sparser. Aside frontotemporal dementia (FTD) primary progressive aphasia (PPA) represents a major group among frontotemporal lobe degenerations (FTLD). This prompted us to determine the major amyloid-β (A-β) species in CSF 1–40, 1–38 and 1–42 in addition to total tau and p-tau181 in patients with FTD (n=25) and PPA (n=12), respectively, a…