Objective motor phenotype assessment of gait and posture in pre-manifest and symptomatic Huntington's disease
H Beckmann, S Rumpf, N Bechtel, HW Lange, C Saft, R Hoffmann, P Kraus, K Barth, S Trautmann, B Landwehrmeyer, R Reilmann · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Patients with Huntington's Disease (HD) develop a progressive impairment of balance and gait (Rumpf et al. 2007), frequently resulting in falls and injuries (Grimbergen et al. 2007). Objective and quantitative assessment of gait and balance in HD may serve as a surrogate marker for motor phenotype dysfunction. Objective: To investigate whether the GAITRite mat (GR) and the Force Plate (FP) (1) are able to detect motor deficits in pre-manifest HD gene carriers, (2) and whether deficits correlate to the severity of phenotype as assessed by the Unified Huntington's Disease Rating Scale Total Motor Score…
